Blar i forfatter "Mishchenko, Ekaterina"

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    • Antibacterial and anti-biofilm activity of novel marine natural product mimics 

      Mishchenko, Ekaterina (Doctoral thesis; Doktorgradsavhandling, 2017-01-20)
      Infectious diseases represent an urgent public health problem globally. Particularly healthcare-associated infections are often complicated by antibiotic resistance and presence of recalcitrant microbial biofilms. On the hunt for effective antibiotics with novel mechanisms of action (MOA), researchers look into largely unexplored natural environments with high biodiversity like the oceans, rich in ...

    • Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes 

      Andersen, Toril; Mishchenko, Ekaterina; Flaten, Gøril Eide; Sollid, Johanna U Ericson; Mattsson, Sofia; Tho, Ingunn; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-04)
      Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal therapy; the chitosan-based nanosystem could both provide antifungal effects and ...

    • Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus 

      Juskewitz, Eric; Mishchenko, Ekaterina; Dubey, Vishesh Kumar; Jenssen, Marte; Jakubec, Martin; Rainsford, Philip; Isaksson, Johan Mattias; Andersen, Jeanette Hammer; Ericson, Johanna U (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-21)
      Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed—either from new chemical classes or drugs with new modes of action. Historically, natural products have been important contributors to drug discovery. In a recent study, the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family ...

    • Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections 

      Giordani, Barbara; Basnet, Purusotam; Mishchenko, Ekaterina; Luppi, Barbara; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-20)
      Vulvovaginal candidiasis (VVC) is a widely spread fungal infection that causes itching, pain and inflammation at the vaginal site. Although common, currently available treatment suffers from limited efficacy and high recurrence. In addition, the growing problem of resistance to azole drugs used in current treatments emphasizes the need for superior treatment options. Antimicrobial polyphenols are ...